Multipurpose Drugs Active Against Both Plasmodium spp. and Microorganisms: Potential Application for New Drug DevelopmentPlasmodium spp.및 미생물 : 신약 개발을위한 잠재적 적용Review Published on 2021-12-242022-08-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 신약개발, 치료제, [키워드] active against Against Antimalarial drugs antimicrobial application Artemisinin Bacteria caused chemotherapeutic agent combination therapy COVID-19 develop development disease Diseases drug drugs Ebola virus disease effective Endemic example focus fungi help Infectious diseases Influenza influenza pandemic information kill knowledge malaria malaria parasites mechanism mechanism of action microbe microorganism microorganisms New not achieved parasite patients Plasmodium Potential problem protozoan parasite Region repurposing the WHO Treatment Virus Disease viruses [DOI] 10.3389/fcimb.2021.797509 PMC 바로가기 [Article Type] Review
Distinguishing gene flow between malaria parasite populations말라리아 기생충 집단 사이의 유전자 흐름을 구별합니다Research Article Published on 2021-12-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis analyzed approach complementary conditions connectivity death descent disease disease control disperse distinguishing drug-resistant effort epidemiological evaluate gene flow Genetic genetic marker Genetic markers genomic Genomic surveillance geographic location geographic locations Guidance identity implementation implication include Infection information interpretability Interpretation Local malaria malaria control malaria parasite malaria parasites Metrics Migration Multiple National observation observations P. falciparum parasite Population populations public health question sampling sequence similar studies Spread strain Surveillance understanding whole genome sequence [DOI] 10.1371/journal.pgen.1009335 PMC 바로가기 [Article Type] Research Article
Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malariaMalawian Plasmodium falciparum 분리물의 전체 게놈 분석은 임상 말라리아에 대한 대립 유전자 특이적 면역의 가능한 표적을 식별합니다Research Article Published on 2021-05-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquired immunity acquisition allele Analysis Antigen antigens approach approaches characterized collected deaths develop disease expand Frequency genes encoding identify immune evasion immune responses Immunity immunologically individual infections investigated isolate longitudinal study malaria malaria parasite malaria parasites multiple allele multiple alleles naturally acquired immunity Plasmodium falciparum polymorphic site polymorphism Prevent Previous studies protective immune response Protein repeated repertoire representing response resulting sequence symptomatic individual symptomatic individuals Symptoms target targets thought Transmission understanding Vaccine vaccine candidate vaccine candidates variant whole genome sequence Whole-genome sequence [DOI] 10.1371/journal.pgen.1009576 PMC 바로가기 [Article Type] Research Article
Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents주요 변이체 표면 항원 암호화 유전자의 진화적 분석은 대륙 내 및 대륙 간 열원충의 개체군 구조를 나타냅니다.Research Article Published on 2021-02-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Analysis analysis Antigen approach asked biological significance complexity conserved country dataset deep sequencing demonstrated detect diagnostic Disease surveillance Diversity DNA DNA sequence DNA sequences domain East effort ENCODE Epidemics Evolution Gabon genomes Globalization health problem hidden hidden markov model HIV Host identify identity immunodominant implication infect Influenza isolate Local malaria malaria parasite malaria parasites Markov methodology Microbiologist MOST outcome parasite parasites pathogen Pathogens Plasmodium Plasmodium falciparum population immunity precluded presence or absence public health recent Recombination sensitivity sequence South America Spread subsequent surface antigen Surface Antigens Surveillance tested to define translational Transmission dynamics Uganda unique VAR var gene var genes variant variants West [DOI] 10.1371/journal.pgen.1009269 PMC 바로가기 [Article Type] Research Article
Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast불확실성이 있는 혈통별 신원 확인은 콜롬비아 태평양 연안에 있는 Plasmodium falciparum 개체군의 연결성을 특징짓습니다.Research Article Published on 2020-11-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accessibility accounted analyses analysis approach approach coast collected component components confidence interval Confidence intervals connectivity descent disease disease control distance ecological epidemiological studies Epidemiological study Epidemiology estimate event FIVE fraction Fractions Frequency genetic data Genotype greater group Hypothesis IBD identify identity implication include Interpretation Intervention knowledge malaria malaria parasite malaria parasites methodological monoclonal organism Organisms P. falciparum parasite parasites Plasmodium Plasmodium falciparum Plasmodium falciparum malaria Population populations presenting Previous studies promote recent required separated Space statistically threshold thresholds Transmission whole genome sequence [DOI] 10.1371/journal.pgen.1009101 PMC 바로가기 [Article Type] Research Article
Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent혈통에 의한 신원을 사용하여 지역 Plasmodium falciparum 말라리아 기생충 개체군 간의 연결성 정량화Research Article Published on 2017-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accessibility analysis approach approach assessment association Author best biological processe biological processes can not chance classic classical clinics collected data set descent detect disease dispersal Divergence drug resistance Ecology effort eliminating endangered species Epidemiology Evolution Genetic genomic data Genomics genotyped human pathogen IBD identity identity by descent increasingly inheritance knowledge Local malaria malaria parasite malaria parasites measure Molecular epidemiology nucleotide organism Organisms parasite Plasmodium falciparum Population power provide proximal Recombination required robust sampling sequenced significant decrease Single nucleotide polymorphism single nucleotide polymorphisms SNPs spatiotemporal Spread Surveillance Transmission transmission patterns whole genome [DOI] 10.1371/journal.pgen.1007065 PMC 바로가기 [Article Type] Research Article
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPlasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다Research Article Published on 2013-02-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing [DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article